Product Overview
SLU-PP-332 (ERRα Agonist) | 5mg
SLU-PP-332 is a novel synthetic small molecule (not a peptide) that acts as a potent and specific agonist of the Estrogen-Related Receptor Alpha (ERRα).
ERRα is a nuclear receptor that serves as a master regulator of mitochondrial biogenesis and oxidative metabolism. In biological systems, this receptor is typically activated by the physical stress of endurance exercise. SLU-PP-332 is chemically designed to bind directly to this receptor, stabilising it in an active configuration without the requirement of physical activity.
In the media, this mechanism is often referred to as an “exercise mimetic.” Research demonstrates that SLU-PP-332 can upregulate the expression of Type IIa (oxidative) muscle fibers and increase mitochondrial respiration rates. This makes it a primary reagent for investigating metabolic syndrome, endurance capacity, and the preservation of muscle function in sedentary or aging models.
Technical Specifications
Chemical Class: Synthetic Small Molecule (Non-Peptide)
Target: Estrogen-Related Receptor Alpha (ERRα) Agonist
Format: Lyophilised Cake/Powder
Purity: >98% (HPLC Verified)
Mechanism: Direct activation of oxidative metabolic pathways
Solubility: Low in Water / High in Organic Solvents (DMSO/PEG)
Solvent: Solvent not included (Sold Separately)
Grade: Analytical Research Grade
Variant Breakdown
5mg Vial: Contains 5mg SLU-PP-332.
Vial Capacity: 3ml.
Quality AssuranceThis compound has undergone rigorous third-party analysis.
HPLC Verified: Independent analysis confirms purity exceeds 99%.
Mass Spectrometry: Confirms accurate molecular structure.
Solubility Check: Verified for dissolution properties (See Technical Data tab for solvent requirements).
Research MechanismIn laboratory settings, SLU-PP-332 is utilised to investigate:
Mitochondrial Biogenesis: The pathway by which ERRα activation increases the number and efficiency of mitochondria in skeletal muscle.
Fatty Acid Oxidation: Research into the molecule’s ability to shift metabolic preference toward burning fat (lipids) rather than glucose.
Endurance Phenotypes: Comparative studies analysing endurance performance and lactate threshold in treated vs. untreated animal models.
Cardiometabolic Health: Investigating the preservation of heart function in models of pressure overload and heart failure.
Safety and HandlingWARNING: This product is exclusively for laboratory research and in vitro use.
Research Only: Not intended for human consumption, bodybuilding, or therapeutic use.
Handling: Wear appropriate personal protective equipment (PPE). This is a potent nuclear receptor agonist.
Storage: Store lyophilised vials in a cool, dry place. For long-term preservation, freezing at -20°C is recommended.
Scientific References
Journal of Pharmacology and Experimental Therapeutics (2023) – “A Synthetic ERRα Agonist Alleviates Metabolic Syndrome in Biological Models.” (The breakout paper on SLU-PP-332). View Article
ACS Chemical Biology (2021) – “Identification of a Synthetic ERRα Agonist That Enhances Mitochondrial Function.” (Detailed chemical characterization). View Article
Nature Communications (2020) – “Estrogen-related receptor alpha (ERRα) is a key regulator of mitochondrial biogenesis and oxidative metabolism.” (Contextual research on the target receptor). View Article
Heart Failure Reviews (2022) – “Targeting Estrogen-Related Receptor Alpha in Heart Failure.” (Research into cardiac applications). View Article
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